Ander Herrera is likely to partner Nemanja Matic in the middle of the pitch against Liverpool on Saturday.
Henrikh Mkhitaryan's status as the creative catalyst-in-chief for showdowns between Liverpool and Manchester United had been mapped out well in advance of arrival in England last July, the only difference being that he was meant to arrive at Anfield - not Old Trafford.
Belgium international Mignolet has been the busier of the two, with 19 saves compared to De Gea's 15, while punching is not a favoured course of action for either man - Mignolet in front of his counterpart 2-1 on this metric.
Liverpool have won just once since August, are out of the Carabao Cup, have struggled in the Champions League and are already seven points adrift of the Premier League leaders.
The Merseyside outfit have only won three of their opening seven Premier League games to leave them in seventh place in the table and seven points off top spot.
"It's always a hard test when you are going to Anfield", Coton told Sky Sports News.
Mourinho's men are even starting to suggest that the glory days of Sir Alex Ferguson's glittering tenure could be returning. The Reds struggled in Mane's absence last season. Again, the one chance they gave up, this time to Joselu, was a golden one, with the Liverpool defenders desperately far apart. I am sure he will be fine for Manchester United at the weekend. In all competitions since, the Reds are 1-4-2.
His current form has seen him score three goals in eight appearances this season.
Will Jose Mourinho splash the cash in the January transfer window?
"Nobody at Liverpool questions the manager", Can added.
Chelsea and United were firmly on his radar with the latter confident of striking a deal.
"I think they will keep playing for the Golden Boot until the last game of the season like they did last year". Or to put it in expected goals terms, Liverpool's expected goals against (9.42) is more than twice as bad as their nominal title rivals Manchester City (3.71) and Spurs (4.41).
Is Mourinho in position to beat his former side to a major signing?
"After I had talked to him, the decision had been made for me". "We do not control the game by having the ball all the time".
Vertonghen expects the battle of the proven marksmen to go down to the wire, with there little to choose between some of the finest finishers in the business.
"I've read a stat which shows that we had 120 shots in the past seven matches, and we only scored seven goals (sic)", Can said. That first half-an-hour is crucial and Mourinho will know that. He wanted everyone to know that the onus was on the home team's manager to open things up in search of the breakthrough.
You could hardly call this a novel observation, but it often seems to be forgotten amid juicy top-six confrontations and Super Sundays.