Atletico full-back Filipe Luis is their one major doubt for the clash, but Koke, Yannick Carrasco and Stefan Savic are all reportedly in contention to start.
Real Madrid players held an inquest in the immediate aftermath of their 0-0 draw at Atletico Madrid. Speaking after the game, Simeone had some interesting comments about the booing, and dropped a hint that Griezmann's future lies away from Los Rojiblancos.
"We had our opportunities, but in the end we knew that we were playing against the best team in the world, and with very little they can score on you", Leganes midfielder Ruben Perez said.
Regarding Griezmann, Simeone said: 'I back members of my family to the death.
Their failures, as always, have led to various rumors of discontent. Atletico, in particular, are desperately struggling in attack and rarely looked like scoring - even though they did have the game's best two chances with Angel Correa's early miss and Kevin Gameiro's shot cleared off the line. As Alvaro Morata continues to shine in England, Karim Benzema is amid a severe form slump with no back-up striker to bail the Frenchman out. The Real boss had the chance to kick a few backsides in his team selection but watched impotently as a tired formula failed miserably again.
The January arrival of Diego Costa should relieve some pressure but Atletico have a lot of important games before then that they need Griezmann to perform at his highest level.
Kuko Ziganda's Los Leones side have vastly underperformed since Ernesto Valverde departed for Barcelona, but they do have an Indian sign over the team from the Estadio de la Ceramica.
Atletico Madrid vs Real Madrid in La Liga will be played on Sunday morning, November 19, 2017.
There was a good tempo to the first half, although the game was repeatedly interrupted by needless fouls an small scuffles.
Lionel Messi was afforded extra rest by Argentina across the international break, so the league's top scorer will be fit and firing on Saturday afternoon. "So I think that means he likes it here", he said.
Leganes striker Nordin Amrabat - on loan from Watford - is still chasing his first goal of the season.
DF Dani Carvajal, 6 - The good news is that Carvajal was available at all after a heart condition, but a yellow for a lunging challenge on Lucas Hernandez suggested he's not quite up to speed.
26-year-old Griezmann recently denied having contact with Manchester United manager Jose Mourinho, and while it seemed inevitable at one point that he would leave Spain for England, Cerezo's claims have further thrown this into doubt.
Real Madrid are still psychologically fragile and if Atletico can land some early punches then they may falter.