In the Palestinian coastal enclave of Gaza, demonstrators chanted "Death to America", "Death to Israel" and "Down with Mr Trump".
Trump's decision Wednesday to recognize Jerusalem as Israel's capital and direct the State Department to begin moving the embassy there comes after months during which Trump's peace team has focused on meeting with Israelis and Palestinians, gathering ideas and building relationships.
Among the landmarks are the Palace of Peace and Harmony - a concrete and glass pyramid designed by Norman Foster that boasts a 1,500-seat opera venue.
Already on Wednesday protests had erupted over the decision in the Palestinian cities of Gaza City and Rafah. "People want to express how they feel out loud and with others, but rain has put a damper on things".
Trump had promised during his campaign and early presidency to make the policy change but deferred the decision when the six-month deadline arrived in June.
He said there would then be a revolt in Asia and armies would then march out of the Far East, possibly a Chinese army, to fight the Antichrist.
George Washington chose the exact spot on the Potomac River and the rest is history.
"Welcome to Jerusalem, the capital of Israel, if you weren't aware of it. We have been aware of this for 3,000 years", he said at the event.
"We have always maintained that Canada should formally recognize Jerusalem as the capital of Israel".
"We should call for and we should work on launching an intifada in the face of the Zionist enemy".
The minister said Jordan rejected the decision, which will increase tension and strengthen the occupation.
Then certain events would happen before the "Great Tribulation", a period of great global instability which Dr. Reagan said would last seven years.
Tillerson was concerned about the implications of the policy change for the peace process, and Mattis about a potential backlash and resulting security threats, one person familiar with the matter said.
Leaders of the Iran-backed Palestinian Islamic Jihad group, Nafeth Azzam and Ahmed al-Batsh, said they were also ready for a new armed struggle.
Turkey condemned the US decision as "irresponsible", saying it bears the risk of completely destroying the ground for peace.
Others uttered profanities. One man held up a picture on his phone of the American and Israeli flags projected onto the Old City walls.
Former Conservative foreign affairs minister John Baird attracted criticism in 2013 when he met a high-ranking Israeli politician in her office in East Jerusalem; that half of the city was captured by Israel in 1967.
"The US decision is an aggression, a declaration of war on us, on the best Muslim and Christian shrines in the heart of Palestine, Jerusalem".
Many allies warned that Trump's decision would negatively affect the peace process between the Israelis and the Palestinians.
Incessant rain dampened reaction on both sides, with a planned celebration in one of the city's main squares canceled and Palestinian protests remaining limited, although a demonstration took place in the Gaza Strip.
In Australia, curious tourists are often shocked to find Sydney is not actually the capital city, and usually told the inland city of Canberra was built as the "bush capital" as a compromise somewhere between Australia's largest city and its competitor to the south, Melbourne.
Other regional countries including Algeria, Iraq and Syria also voiced condemnation against the US move. Church leaders will be anxious to protect Christian sites. Some 200,000 Israelis living in settlements in occupied East Jerusalem, illegal under international law, will also celebrate.
Kushner and Greenblatt expect in the long run Trump's announcement won't hurt and could help prospects for peace, the two officials said.