ALS is also called Lou Gehrig's disease, after the famous baseball player who retired in 1939 because of the condition.
"We are deeply saddened that our beloved father passed away today", his children said in a statement. His ability to understand concepts of time and space and relay them to the average person was not only a gift, but necessary in our modern world in which people, even those of us with a fascination for such topics, do not have the same skills needed to decipher the universe on such a level.
The power of his intellect contrasted cruelly with the weakness of his body, ravaged by the wasting motor neurone disease he developed at the age of 21.
But news of his death exploded like a supernova in the world of cosmology - where, despite his disability, Prof Hawking had stood like a colossus.
The comments don't stop there, either.
"My goal is simple", he once said. He next got the chance to attend Hawking's lectures when he joined the Cambridge University as a PhD student. Before joining The Post in 2006, she worked as a freelancer in London for the New York Times and People magazine. It sold 10 million copies and was translated into 40 different languages. Hailed as one of the most brilliant theoretical physicists since Albert Einstein, Hawking never won a Nobel Prize.
"The greatest enemy of knowledge is not ignorance, it is the illusion of knowledge".
Stephen Hawking's Grand Design: Hawking addresses three more of the most contentious issues that surround scientific understanding. "So then in the evening he and his nurse came with".
"My love and thoughts are with his extraordinary family".
One of the most difficult things to get your head around when you are told that you have MND is the fact that the prognosis is so bleak.
The contents of the message were not made public.
California Institute of Technology physicist Sean Carroll says the Nobel isn't given to the smartest scientist or the one who makes the great contribution to science. "There is no heaven or afterlife for broken down computers; that is a fairy story for people afraid of the dark", he added.
"May you keep flying like superman in microgravity." - to NASA astronauts in 2014. He was also a fierce critic of President Donald Trump, saying back in 2016 that the current president "will cause avoidable environmental damage" by continuing to deny climate change and withdrawing from the Paris climate change agreement.
"He did a lot to popularise physics to the community by his social presence, talks, videos, books, etc. He was a great loss to the scientific community, a man who was truly the face of Physics". "Think of it as a kind of vacuum energy permeating the fabric of spacetime that defies measure", the scientist said.
"We need to employ effective management in all areas of its development", he said.
Scientist and broadcaster Professor Brian Cox tweeted: 'Sad to hear about Stephen Hawking. "It belongs to one exceptional family".
"He was elected a Fellow to the Royal Society at the exceptionally early age of 32. A sad day for all of us".